Fellows are selected for their “spirit of innovation” in university research, helping to generate groundbreaking inventions that have a tangible impact on quality of life, economic development and the welfare of society.

Trent is the only 2020 fellow from the state of Kentucky and the seventh from UofL. The 2020 Fellow class of 175 inventors represents 115 research universities and governmental and non-profit research institutes worldwide.

“It’s certainly an honor and I think it’s a testament to the drug discovery program we’ve built at the Brown Cancer Center and UofL through many collaborations and partnerships,” said Trent, a professor of medicine and the Wendell Cherry Endowed Chair in Cancer Translational Research. “The benefits of UofL are the support we’ve had for taking creative activities through intellectual property protection to the commercialization grant programs.”

As deputy director of basic and translational research at the , Trent’s Molecular Modeling Facility uses computer predictions to understand and virtually test how drug and disease molecules might interact before real-world testing in the lab.

Trent also runs the UofL partnership with , a company that created a grid that uses the processing power of thousands of computers in schools across Kentucky that Trent uses to screen potential drugs and compounds against and, most recently, . The DataseamGrid has the capability to screen millions of potential compounds against molecular targets in only a few days.

Trent holds more than 50 patents, 24 of which are U.S., and numerous licenses and option agreements with potential commercial partners. Among other accolades, he received the Apple Science Innovator Award and the 2019 , the latter awarded through the UofL Commercialization EPI-Center.

“We’re very proud of John, and all his work to create innovations that have the power to advance our health,” said Kevin Gardner, UofL’s executive vice president for research and innovation. “The fact that John and other UofL researchers before him have received this honor, the highest for academic inventors, shows our university’s commitment and leadership in research, invention and developing technologies that change and improve the way we work and live.”

Previous Fellows from UofL include Suzanne Ildstad and Kevin Walsh (2014), William Pierce (2015), Paula Bates (2016), Robert S. Keynton (2017) and Ayman El Baz (2019).

Trent’s induction, paired with Bates’ four years earlier, also makes the two of them one of only a handful of married couples to be named fellows. The duo also frequently works together, including developing the aptamer that would become the basis for innovative technologies since applied to fight and novel .

The 2020 NAI Fellow class collectively holds more than 4,700 issued U.S. patents.

Among the class are 24 recipients of National Academies of Sciences, Engineering, and Medicine honors, six recipients of American Academy of Arts & Sciences honors and two Nobel Laureates, as well as other honors and distinctions. The complete list of 2020 NAI Fellows is available .

Keynton is a professor and the Lutz Endowed Chair of Biomechanical Devices of the Department of Bioengineering at the J.B. Speed School of Engineering. Keynton was founding chair of the bioengineering department, which under his tenure grew into the most productive basic and translational research department in the Speed School. He is also the director of research initiatives in the office of the executive vice president for research and innovation.

“I am humbled by the nomination and support from my colleagues at UofL and I am truly honored to have been selected to be a member of the National Academy of Inventors and to be associated with such a prestigious group,” Keynton said.  

Keynton’s research focuses on Lab-on-a-Chip devices, microsensors, biomedical devices and biomaterials. He joined UofL in 1999 and has co-founded three companies with UofL colleagues. His career has centered on multidisciplinary research, which includes more than $51 million of funding from agencies such as the National Institutes of Health, the National Science Foundation, Wallace H. Coulter Foundation and the Veterans Administration.

“Professor Robert S. Keynton is a leader in research and innovation at UofL and the nation and around the world,” said William Pierce, UofL executive vice president for research and innovation, who was named an NAI Fellow in 2015. “As founder of our department of bioengineering, he has built a talented faculty as he built his own research efforts. He has brought in many millions of research dollars in research funding individually and has led or helped lead development of our Nanotechnology Center, our Coulter Project initiative, our REACH (NIH) for proof-of-concept centers, and our NSF I-Corps Centers to provide opportunity for so many. Currently he leads efforts that will provide opportunities for untold numbers of students, fellows and future alumni. We are proud to have Rob as one of our leading innovators, inventors and scientists.”

Keynton is the fifth UofL researcher to be named an NAI Fellow. In addition to Pierce in 2015, honorees have been Suzanne T. Ildstad, MD, and Kevin M. Walsh in 2014 and Paula J. Bates in 2016.

With the election of the 2017 class there are 912 representing more than 250 research universities and governmental and non-profit research institutes. The 2017 Fellows are named inventors on nearly 6,000 issued U.S. patents, bringing the collective patents held by all NAI Fellows to more than 32,000 issued U.S. patents.

The new NAI Fellows will be inducted April 5 as part of the of the National Academy of Inventors at the Mayflower Hotel, Autograph Collection in Washington, DC.