“Our mission is to transform the health of the communities we serve and the Heart Hospital delivers on that promise in life-changing ways,” said Tom Miller, CEO of UofL Health. “We have dedicated the space, assembled the technology and most importantly we have the academic expertise and commitment to make a difference in Kentucky’s biggest health threat.”

According to the most recent Centers for Disease Control and Prevention data, heart disease remains Kentucky’s leading cause of death. The Heart Hospital is designed to change that statistic by saving lives and improving heart health. From the routine to the rare, and advancing research, the specially trained staff is dedicated to taking care of heart patients and their families.

“The UofL Health – Heart Hospital represents the future of heart care, in Kentucky and beyond,” said Lori Stewart Gonzalez, University of Louisville interim president. “This hospital combines comprehensive clinical care with academic expertise, training and breakthrough discoveries to advance heart care around the world.”

The Heart Hospital has more than 100 beds dedicated for heart patients. Rising 15-stories above downtown Louisville, with nearly 280,000 square feet, it provides leading-edge heart care on UofL Health’s academic medical campus. It includes six dedicated cardiac cath labs, two hybrid operating rooms, three electrophysiology labs and three cardiac operating rooms collectively equipped for TAVR, Watchmen Flex and heart transplant procedures. More than 300 heart care professionals make up the Heart Hospital team, with preventative and follow-up care extended to more than 30 locations across Kentucky and Indiana.

“Convenient access is essential to impactful care, that’s why the Heart Hospital extends care beyond downtown and into our community,” said , UofL Physicians – Cardiology Associates. “With early diagnosis, customized interventions and regular check-ups, our goal is to prevent the need for advanced care. But, if advance care is needed, the Heart Hospital means patients get the very best care, and still stay close to home.”

As part of UofL Health and through its alignment with both the University of Louisville School of Medicine and the Cardiovascular Innovation Institute, the Heart Hospital leverages the advantage of academic medicine. Medical heart firsts attributed to the UofL Health team include three world’s first transplants and cardiac stem cell procedures, along with a first-in-the nation procedure to relieve the symptoms of heart failure to improve cardiac function and quality of life. The Heart Hospital team is also credited with dozens of state firsts and has celebrated more than .

“When you come to the Heart Hospital you get access to the heart care standards of the future, today,” said , chair of the UofL Department of Cardiovascular and Thoracic Surgery. “We leverage our academic advantage to save and improve more lives. I’m proud to be part of a team committed to research and developing innovative heart care.”

All UofL Health – Heart Hospital locations are now available to assist patients, downtown and at more than 30 locations across the community. 

Jaimin Trivedi, assistant professor and director of clinical research and bioinformatics in the UofL Department of Cardiovascular and Thoracic Surgery, was lead author on an article  last month that detailed the findings.

Trivedi and his colleagues in the department used data from the United Network for Organ Sharing (UNOS) database to analyze changes in the percentage of heart transplants for Black, white and patients of another race since 1987, when the database was established. They analyzed de-identified records for a total of 105,266 adults listed in the database for heart transplants from 1987 through 2020 by Black, white or another race, and the 67,824 patients from the list who received a heart transplant.

The proportion of Black patients on the UNOS heart transplant list increased from 7% in 1987 to 25% in 2019 and those who received transplants increased from 5% in 1987 to 26% in 2019.

According to , 14.2% of the U.S. population is Black or African American alone or in combination with another race.

“Black patients historically have had poorer access to heart transplants, evident in our study as fewer patients listed for transplant and fewer patients actually receiving the transplant,” Trivedi said. “But, as the general health care of heart transplant patients improved over the years and the knowledge of racial disparities came into light, all these things came together and eventually the proportion of Black patients listed increased over time.”

While the numbers indicate parity among patients of different races, Trivedi said an analysis of equity also must consider the increased risk for heart disease among Black patients. 

“The Black population is at higher risk of cardiac disease based on the CDC data, so that means there are more Black patients likely to have heart failure and they are more likely to require a heart transplant,” Trivedi said. “If we are just looking at two numbers in the proportion of patients transplanted right now, it’s improved, but we have to look at it from the perspective of how prevalent heart disease is in the Black community and then how many of them are getting a transplant. So more research has to be done before you can meaningfully say whether there is equity in access to heart transplants.”

The researchers also looked at three-year survival of heart transplant patients. Post-transplant outcomes improved for all patients over the study period due to better post-transplant care, more rapid treatment of transplant rejection and other factors, Trivedi said. Outcomes also improved for Black patients, which are reaching levels comparable to white and other patients in recent years.

“There has been a general improvement in transplant survival outcomes across the races. Black patients tended to do slightly more poorly than white patients, but when we look at more recent data over the past five or six years, we have seen that Black patient survival also has been improving and it is reaching par.”

Another factor affecting post-transplant survival is access to quality health insurance. With this in mind, the researchers compared data for individuals with private insurance with those who had Medicare or Medicaid, information that was included in the database since 1994.

They found that post-transplant survival for Medicare and Medicaid patients improved over time but remained marginally below that of privately insured patients. The improvement in survival of Black patients was seen through all insurance classes, particularly since 2012, which Trivedi said could be multifactorial but also partially due to reliable insurance coverage after the application of the Affordable Care Act.

The team, led by Mark Slaughter, MD, professor and chair of the Department of Cardiovascular and Thoracic Surgery in the UofL School of Medicine and lead cardiothoracic surgeon at UofL Health – Jewish Hospital, performed the implant of the investigational device on Aug. 20.

The artificial heart, Aeson, developed by French medical device company CARMAT, serves as a bridge to transplant for patients with end-stage biventricular heart failure – heart disease affecting both left and right sides of the heart – allowing more time for the patient to receive a permanent heart organ transplant. More than 3,400 individuals in the U.S. currently are awaiting a heart transplant and there are few other treatment options for patients with biventricular heart disease.

“We are excited to provide this new technology to patients in Kentucky and the surrounding region and be one of the first U.S. centers to implant this new total artificial heart” Slaughter said. “This device has the potential to save the lives of critically ill patients suffering from biventricular heart failure who currently have very limited treatment options.”

The new total artificial heart was implanted into a middle-aged man from Southern Indiana with severe biventricular heart failure during a seven-and-a-half-hour surgery. The recipient, whose identity is being withheld upon request, was referred to the Advanced Heart Failure Therapies Program at Jewish Hospital. The patient currently is doing well in the cardiac surgery ICU. The Advanced Heart Failure Therapies Program at Jewish Hospital is the only program in the area that is performing heart transplants, the latest in mechanical circulatory support and cell-based therapies for advanced heart failure.

“Innovative care is what put Jewish Hospital on the world map,” said John Walsh, chief administrative officer at Jewish Hospital. “UofL Health was formed, in part, with a promise to preserve and build on the transplant legacy for generations to come. This procedure is another lifesaving milestone.” 

The new device is designed to solve limitations of left-ventricular assist devices (LVAD), which pump blood in just one chamber, by pumping blood in both heart chambers. Aeson also contains biosensors that detect the patient’s blood pressure and position and automatically adapts cardiac output according to the sensor information. It is fully implanted as a heart replacement and powered by a portable external power supply.

“We are honored that our device is implanted at UofL Health – Jewish Hospital, which is recognized throughout the United States for its quality of care and cardiovascular research” said Stéphane Piat, Chief Executive Officer of CARMAT. “I would like to congratulate the teams at Jewish Hospital, the University of Louisville, as well as our technical and medical staff, on this exceptional milestone for both patients and our company.”

The device is medically approved in Europe, where approximately 20 have been implanted. The first Aeson artificial heart in North America was implanted in July at Duke University.

This is not the first time University of Louisville physicians and Jewish Hospital have made artificial heart history. Just over 20 years ago, on July 2, 2001, UofL cardiothoracic surgeon Laman Gray led the surgical team that implanted the first self-contained artificial heart in the United States at Jewish Hospital. The AbioCor artificial heart was implanted into Robert Tools, who lived five months on the device. The UofL surgical team also performed the first heart transplant in Kentucky at Jewish Hospital in 1984.

“As we end American Heart Month, it’s the perfect time to share this wonderful news,” said Mark Slaughter, MD, surgical director of heart transplant for University of Louisville Physicians and Jewish Hospital, and professor and chair, Department of Cardiovascular and Thoracic Surgery, UofL School of Medicine.

Dr. Slaughter performed the 500^th transplant on Feb. 21, on a 59-year-old man who had a left ventricular assist device implanted to support his heart until the donor heart was available for transplant. An LVAD is a surgically implanted mechanical pump attached to the heart.

The first heart transplant at the hospital, which was also the first heart transplant in Kentucky, took place on Aug. 24, 1984, performed by the University of Louisville’s Laman Gray Jr., MD. The state and region waited in suspense as 40-year-old Alice Brandenburg received a new heart. The surgery, which took seven hours, was groundbreaking at the time. The UofL and Jewish Hospital transplant team is one of the leading providers of organ transplantation in the country.

“Jewish Hospital is a place where miracles happen every day and patients’ lives are changed forever,” said Ronald Waldridge II, MD, president of Jewish Hospital. “Five-hundred hearts is much more than a milestone. It represents the life-changing impact on our patients, their families and the entire region. Together, with UofL, Jewish Hospital’s Trager Transplant Center is investing in research, technology and advance procedures to increase access to transplant services.”

On Wednesday, doctors and heart transplant recipients gathered at the Jewish Hospital Rudd Heart and Lung Center to celebrate the 500^th milestone and the many lives that have been saved over the years thanks to heart transplantation. 

“The 500^th heart transplant is a reminder of the commitment by Jewish Hospital and the University of Louisville to provide advanced therapies for patients with advanced heart failure,” Slaughter. said. “We’ve come a long way since Dr. Gray broke ground with that first heart transplant more than 30 years ago. Every day, we continue to advance the science of heart transplantation here at UofL and Jewish Hospital. I’m excited about the future of this program, and I’m confident that we’ll mark a lot more milestones over the next 30 years.”

For Dr. Gray, Wednesday’s celebration marked decades of dedication to the heart transplant program.

“After performing the first heart transplant, it means a lot to me to see the 500^th and where we are today,” Gray said. 

Gray continues to research new ways to help patients with heart disease at UofL’s Cardiovascular Innovation Institute, a center focused on bio-adaptive heart innovations, including the integration of heart-assist device, biodfeedback sensors and related technologies. In 2001, Gray and the Trager-UofL surgical team implanted the first fully implantable replacement heart, the AbioCor.

Today, patients like Jeffrey McMahan continue to benefit from the heart transplant program. McMahan was the center’s 479^th heart transplant, and he attended the celebration on Wednesday along with other recipients.

Before his heart transplant, McMahan, 61, was no stranger to the procedure – it had helped save many of his family members. The Memphis, Indiana, resident had four family members receive heart transplants – two by University of Louisville surgeons at Jewish Hospital. In 2015, McMahan learned he, too, needed one.

“I was serving in the military at Fort Knox when I developed a cough,” said McMahan. “It finally got bad enough that doctors flew me to Jewish Hospital, where I was diagnosed with a cardiomyopathy, a condition where the heart muscle is weakened. I learned that I would need a transplant in the next 10 years, but that timeframe quickly changed to 10 months after my condition worsened.”

On Aug. 15, 2015, McMahan was added to the organ donor transplant list. A month later, he received the transplant that forever changed his life.

“I wouldn’t have lived without the transplant,” McMahan said. “It means a lot to be here to celebrate the 500^th. I’m forever thankful to the transplant team that helped save my life and gave me more time with family.”

It has been an exciting year for the Jewish Hospital Trager Transplant Center and University of Louisville team. In December 2017, the center – a joint program with the UofL School of Medicine and KentuckyOne Health – broke its all-time record for number of organs transplanted in the center’s 53-year history, with 175 organs transplanted in a year. The center also achieved several other milestones in 2017, including its 5,000^th transplanted organ, its 3,000^th kidney transplant and its 900^th liver transplant. In addition to Kentucky’s first heart transplant, the program is known for performing Kentucky’s first adult pancreas, heart-lung and liver transplants.

But the 500^th heart transplant and other milestones wouldn’t have been reached without organ donors, noted David Lewis, director of Transplant Services at the Jewish Hospital Trager Transplant Center.

“We often encourage people to sign up as organ donors to help save lives. The need for organ donors is unfortunately greater than the number of people who donate, so each day, an average of 20 people pass away while waiting for a transplant in the United States,” Lewis said. “Knowing that we have helped save 500 people in need of a new heart is a wonderful feeling, and it would not be possible without the donors and their families.”

Video of the first heart transplant at Jewish Hospital is .����