The gift, from former Speed School alumni fellow Scott McReynolds ’86 and his wife Jennifer ’84, also represents the kickoff to Raise Some L, UofL’s annual day of giving.

Beginning at 6:02 p.m., Tuesday, Oct. 18, and continuing through midnight, Wednesday, Oct. 19, Raise Some L runs for 1,798 minutes in honor of UofL’s founding year. The 30-hour drive, traditionally held during Homecoming Week, is a chance for the Cardinal Community to support students, research and campus initiatives that help build a better world.

The opportunities created by the gift will help underprivileged youth gain critical skills to tackle the world’s problems. The $450,000 donation will provide last dollar scholarships, tutoring and bridge programming, Robotics Research Fellowships within the Louisville Automation and Robotics Research Institute (LARRI), summer research experiences for Central High School students at LARRI and an immersive learning experience trip to Boston, Massachusetts, the hub of robotics research and innovation.

“Gifts like these are inspiring and life-changing,” Interim President Lori Stewart Gonzalez said. “This generous support and other funds raised during our annual day of giving will help fuel the success of our students, advance our research and innovation initiatives and improve our community.”

There have also been several sizable donations that have already been pledged in advance of the day including: ��

• Three gifts to the School of Medicine designated for research in the amounts of $1 million, $400,000 and $100,000 from anonymous donors
• $50,000 gift to the Community Band in the School of Music from an anonymous donor
• $33,675 gift to the Breonna Taylor Memorial Scholarship Endowment by Jill Whitten in memory of her parents Ann W. and Donald J. Roth
• $25,000 gift to establish the Karlynn BrintzenhofeSzoc “Scholars in Healthcare Social Work” Scholarship, funded by Ronald Z. Szoc and Karlynn BrintzenhofeSzoc
• $15,000 challenge match that will support various areas across the university by Hank and Rebecca Conn
• $10,000 gift to the UofL Health Brown Cancer Center by Jason Chesney
• $10,000 match gift for the LGBTQ Center by Steve Bass

“UofL’s Day of Giving Campaign is a great way to support the continued success of the Cardinal community by making a gift to an area that inspires you,” Interim Vice President for Advancement Julie Dials said. “This year’s Day of Giving is especially critical as we navigate challenging times to help create thriving futures for our students.”

Raise Some L 2022 begins at 6:02 p.m., Tuesday, Oct. 18 and runs through midnight, Wednesday, Oct. 19. Interested participants can make a gift to any area of the university at .

In addition to online giving, in-person donations may be made at the Raise Some L Belknap Campus and Health Sciences Campus headquarters from 10 a.m.- 2 p.m., Wednesday, Oct. 19.

The Student Organization for Alumni Relations will be stationed at Raise Some L headquarters at the quads of both campuses with snacks, activities and additional information.�� Share the word about Raise Some L by using #RaiseSomeL.

For information on other UofL Homecoming Week events, please visit the .

The funds will be targeted for an expansion and renovation of the Planet Fitness Kueber Center, which houses training facilities and offices on the UofL campus for the Cardinals’ men’s basketball, women’s basketball and women’s lacrosse teams. Details on the project will be announced at a later date.

“We are incredibly grateful for the generosity and support of the Galt House,” said UofL Vice President and Director of Athletics��. “The sponsorship agreement avails us the opportunity to experience the amazing renovation of the hotel rooms and its amenities going forward. The larger meeting space allows more supporters to experience some of our annual events for the first time. The Schneider family has been long time supporters of the university and we are very fortunate to forge this mutually beneficial partnership for years to come.”

In recognition of the generous gift from the Al J. Schneider Company, UofL will name the football suite levels on the east and west sides of the Cardinal Stadium as The Galt House Hotel Suite Level. Signage throughout the stadium will identify the areas, as well as inclusion on the suite level tickets.

In addition, special events for Cardinal Athletics, such as the annual Football Kickoff Luncheon and Basketball Tipoff Luncheons, will be staged in the renovated ballrooms, restaurants and public areas of the Galt House Hotel. The gift will be paid over a 10-year period.

“UofL Athletics is a centerpiece of our community, and this is a chance for us to be part of that excitement,” said Scott Shoenberger, president and CEO of the Al J. Schneider Company, which owns the Galt House. “We are thrilled to be able to support another iconic Louisville institution in this way, and look forward to a long-standing, mutually beneficial partnership.”��

Over the past several years, the Al J. Schneider Company has invested more than $80 million in The Galt House, which has undergone a massive renovation that touches nearly every corner of the property, including guest rooms, meeting spaces, lobby areas, and the hotel’s four dining areas.��

The new program will be named the Dunbar CAR T-Cell Program.

“This gift will allow both kids and adults to be treated right here in Kentucky with the most innovative cell-based immunotherapy being developed,” said Jason Chesney, MD, PhD, director of the UofL Brown Cancer Center.

In CAR T-cell therapies, immune cells are extracted from the patient’s own blood and then are genetically modified to fight cancer. The modified cells are infused back into the patient where they fight the cancer and create long-term immunity to its recurrence. In addition to dramatic treatment results, CAR T-cell immunotherapy leads to fewer toxic side effects than traditional chemotherapy.

“Patients who have been treated with all the conventional therapies who then underwent treatment in clinical trials with CAR T cells had dramatic response rates. Eighty-three percent of kids in the original trial who had lethal, terminal B-cell acute lymphoblastic leukemia responded to this therapy,” Chesney said.

CAR T-cell therapy is FDA approved for treating patients who have B-cell acute lymphoblastic leukemia, who are mostly children, as well as adults who have an adult form of a B-cell (non-Hodgkin’s) lymphoma. This technology also is being tested for treatment of other cancers through clinical trials. Until now however, these treatments have been available primarily in larger coastal cities outside of the Midwestern United States.

“At the UofL Brown Cancer Center, we feel strongly that these advanced therapies should be available not just to people in New York or California or Texas, but to people in Kentucky, Indiana, Tennessee and Illinois. If you live in these areas, it is going to be very hard for you to be treated a thousand miles away with a therapy like this,” Chesney said. “And any patient with health assistance through Medicaid is likely to be covered only if the treatment is delivered within the state.”

The Dunbar CAR T-Cell Program will include laboratories for manufacturing the CAR T cells and will administer both FDA-approved and clinical-trial therapies to adult and pediatric cancer patients. The program intends to expand clinical trials and clinical research using CAR T-cell therapy to treat additional cancer types in Louisville. The goal is for the facilities to be fully functional and receiving patients by Sept. 30, 2020.

Tom Dunbar’s son, Evan, lost his battle to cancer with neuroblastoma in 2001 at the age of 6. In 2009, Wally Dunbar, Tom Dunbar’s father, lost his battle with melanoma. This year, Tom’s physician wife, Stephanie Altobellis, M.D., helped identify his own cancer.

“Kentucky is at ground zero, with the nation’s highest rates of cancer diagnosis and death,” Tom Dunbar said. “It’s completely unacceptable. We have to lead the charge right here where the need is the greatest and we can do the most good. We need treatments that are not toxic. Watching our loved ones miserable with pain, often just from the treatments, and yet still die in front of us simply can’t be the best that we can do.”

How CAR T cells work

T cells are key immune cells in the body that attack cancer cells. CAR T cells are T cells that have been isolated from the patient’s blood and then genetically modified to more effectively destroy the cancer cells.

A non-infectious virus is used to insert genes into the T cells that express a receptor specific to proteins, or antigens, present on cells of the cancer to be treated. The armed, loaded T cell is drawn into close proximity to the cancer cell, and the new cell sends a signal for the T cell to kill the cancer cell.

“We add the receptor gene into the T cells, which makes them stick to the cancer cells like Velcro,” Chesney said. “In theory, all cancers have unique antigens on their surface that we can target with this approach. We are nudging the immune system on to really hit the target, in this case the cancer cells.”

The sophisticated technology requires the use of a specialized clean room for genetically manipulating the patients’ immune cells. The clean rooms, known as Good Manufacturing Practice (GMP) laboratories, require specialized documentation and equipment to protect the individuals working there and ensure a sterile and controlled environment for the cells.

The Dunbar CAR T-Cell Program will include two GMP laboratories, one for use in pediatric therapies to be named for Evan Dunbar and one for adult therapies to be named for Altobellis. These labs are intended to support not only clinical trials and patient treatment at the UofL Brown Cancer Center, but also in other health centers in Louisville, Lexington and elsewhere.

“Our goal for the Dunbar CAR T-Cell Program GMP labs is to be a hub manufacturing facility for CAR T cells, not just in Kentucky, not just in the region, but for the entire country,” Chesney said.

For Dunbar, the goal is to improve cancer treatment for patients.

“The burden is on each of us to create a better future for our children,” Dunbar said. “Working together, we can ensure Louisville is equipped to provide the durable cures, free of side-effects, that we desperately need.”

Check out the video:

The editors found themselves with dozens of boxes of bound BloodHorse magazines dating back to 1940 and no place to put them. They were a duplicate set, and some of them were even bound in a green cloth valuable to collectors.

“These magazines contain a wealth of historical information, and the last thing we wanted to do was throw them into a dumpster,” said Eric Mitchell, bloodstock editor at BloodHorse. “One of our first calls was to Sean (Beirne) at the UofL Equine Industry Program, which BloodHorse has supported for years by offering internships to students, providing guest lecturers, and hiring graduates of the program.”

That’s why, one cold day in March, Beirne and equine administrative assistant Liz Young found themselves driving to Lexington in a rented truck. What they came back with is unique to UofL.

BloodHorse Magazine’s donation to the University of Louisville Equine Industry Program marks the first time the program has been the recipient of a book collection. While the equine program is a part of the College of Business, the donated volumes will be kept in Ekstrom Library on Belknap Campus.

The collection consists of a continuous run of BloodHorse Magazine from 1940 to 2018 bound in 332 volumes. It contains more than 4,100 issues, many bound in green cloth. Also donated were a selection of Goodwin’s Turf Guides that date back to the mid- to late-1800s.

“This donation gives researchers an enormous amount of thoroughbred racing history and breeding in one place,” said Beirne, director of the Equine Industry Program. “On behalf of our students, faculty members and researchers, I thank BloodHorse for trusting UofL with this invaluable collection.”

UofL’s Equine Industry Program offers an accredited business degree with an equine focus. Graduates can be found in all aspects of the industry, from training to broadcasting.��

BloodHorse offers comprehensive and broad-ranging coverage of thoroughbred racing and breeding. The company’s website, , offers daily news, analysis, race entries and results.

“We were thrilled that UofL wanted the books and recognized their value,” Mitchell said. ��“It really does offer peace of mind that they have a home where they are appreciated and used.”

Joule’s son lives with type 1 diabetes.

To honor her late father and help improve the lives of those with type 1 diabetes, Joule has given $500,000 to the University of Louisville Foundation to establish the William Marvin Petty, MD, Research Fund. The fund is designated to support type 1 diabetes research at the UofL School of Medicine.

“I saw the toll diabetes took on my dad, and now my son is faced with the same disease,” Joule said. “I was��not happy that medical research has not come up with anything new in the 40 years my son has been suffering. I am putting my assets behind the UofL research team.”��

That research team includes Haval Shirwan, PhD, and Esma Yolcu, PhD, of the UofL Department of Microbiology and Immunology, who are working to develop techniques to prevent and treat type 1 diabetes with particular focus on transplantation of islet cells.

Type 1 diabetes is a chronic autoimmune disease in which the pancreas does not produce enough insulin, a hormone required to convert glucose to energy in the body. There is no cure for type 1 diabetes, and standard treatment involves regular injections of insulin, which is far from keeping blood sugar in balance.

Insulin is produced in the pancreas by a type of cells called islet cells. Individuals with type 1 diabetes have too few or altogether lack the type of islet cells that produce insulin to keep glucose at the proper level. In recent years, physicians have developed a treatment in which they transplant the needed islet cells into a patient. However, the patient’s immune system often rejects the transplanted islet cells over time, attacking and killing them. To keep the transplanted cells alive, patients must take immunosuppression medications, which have a number of undesirable side effects.

At UofL, Shirwan and Yolcu have pioneered a process to create a manufactured protein known as Fas ligand (FasL), to protect the islet cells from destruction by the patient’s immune system. This process, patented by the UofL Office of Technology Transfer, is called ProtEx^��technology. ProtEx is used to create FasL, which is then applied to islet cells to protect them from destruction by the immune system once they are transplanted into the patient.

Preclinical research has shown that FasL is highly effective in protecting islet cells in small animal models. However, additional testing is necessary before the therapy can be used in humans.

“Ms. Joule’s contribution will enable us to achieve an important milestone for further development of the technology towards clinical translation by performing efficacy and safety studies. We are very grateful for that support,” Shirwan said.

Greg Postel, MD, executive vice president for health affairs at UofL, said the university is grateful for the contribution to research by and in honor of members of the Louisville community.

“We are extremely pleased that Ms. Joule has elected to support this very promising research at the University of Louisville,” Postel said “We believe her donation will allow this research to improve the lives of type 1 diabetic patients sooner rather than later.”

Until recently, Friends Eye Center in Tamale, Ghana, lacked basic ophthalmic equipment and the center’s surgical microscope was outdated and cumbersome. The center, directed by Seth Wanye, MD, provides vision care for nearly 3 million residents of the West African nation and serves as a training site for future ophthalmologists.

Henry J. Kaplan, MD, chair of the UofL Department of Ophthalmology and Visual Sciences, visited Friends Eye Center during a medical mission trip several years ago.

“Most of the equipment they had was non-functional. The equipment we gave them we no longer use because of the acquisition of more technologically-advanced diagnostic devices,” Kaplan said. “Many of the people there have totally lost their eyesight and are dependent on their relatives and other support structures, which presents an enormous economic burden.”

Wanye, who regularly visits UofL to enhance his surgical skills, was visiting Louisville in 2015 when Kaplan offered to donate the equipment to his center in Ghana.

“It was like a dream come true,” Wanye said. “It helps me perform thorough examinations of the eye so I can identify other problems, not just the cataract that you can see. It also gives the patients comfort and they are fascinated.”

Shipping large items to Africa is not a simple process, however, and it was nearly a year before the equipment reached the center. Thanks to multiple organizations that shared the expense and worked to transport the instruments, the Friends Eye Center now has a slit lamp, which allows Wanye to examine his patients’ eyes more precisely, a better surgical microscope, chairs for both the surgeon and the patient, and an auto refractor for determining eyeglass prescriptions.

Wanye, who was the only ophthalmologist serving the Northern and Upper West regions of Ghana until a colleague joined him last year, also works with future physicians in the center to introduce them to the specialty of ophthalmology. Most Ghanaian medical students choose other specialties since ophthalmology is not a medical priority in Ghana.

“You have so many other diseases that are killing people. They say eye diseases don’t kill so they are overlooked,” Wanye said. But he has seen that restoring vision allows individuals to regain their independence and enables children to go back to school.

“When you go out into the villages, people are poor, they don’t have money but they are blind. So we will get the resources and do the surgery.”

Wanye receives funding from non-governmental organizations, such as and the , to provide eye screenings and perform between 2,000 and 4,000 cataract surgeries each year. In addition to screenings and surgeries on location, Wanye provides care for patients in the Friends Eye Center.

“To be one doctor that serves millions of people is not a trivial task. He does it because of a love and conviction for the good that he is doing. I really do admire what he’s doing and that’s why we are more than happy to assist him,” Kaplan said. This is the first time UofL’s ophthalmology department has donated equipment to a foreign health-care organization.

Wanye hopes to establish a regular exchange between UofL ophthalmologists and the center, similar to a program in which residents and faculty members from the UofL Department of Pediatrics travel to the Tamale Teaching Hospital several times each year. Tamale is an official sister city to Louisville.

“My dream is to have some continuous program, especially with the residents’ program here, so we would have residents coming to Friends Eye Center,” Wanye said. In the meantime, he is grateful to UofL for the donated equipment. “We know how valuable they are and how expensive they are. They will help us deliver more quality service to our people. Thank you to everyone at UofL,” Wanye said.

Equipment photos courtesy Friends Eye Center, Tamale, Ghana