The center is located in the UofL Physicians Outpatient Center, 401 E. Chestnut St., and serves as the clinical arm of the UofL Diabetes and Obesity Center headed by Aruni Bhatnagar, PhD, which focuses on research into prevention of diabetes.

“It is immensely gratifying to see the science of diabetes prevention being implemented to improve the public’s health,” Bhatnagar said. “It is through programs such as this that we will turn the tide in the fight against the epidemic of type 2 diabetes.”

In addition to the CDC recognition, the UofL Physicians Diabetes and Obesity Center, in a partnership with ULP Department of Medicine, is recognized by the American Diabetes Association for Quality Diabetes Self-Management ����ֱ�� and Support.

The ULP Diabetes and Obesity Center was created in part from support by KentuckyOne Health to provide preventive care and education and to promote research in diabetes and obesity. The Center is directed by Sri Prakash Mokshagundam, MD.

“Once you have diabetes, you can’t get rid of it, but if you have prediabetes, which is higher than normal blood sugar levels, or if you are at risk for developing diabetes, you can prevent it with lifestyle changes,” Mokshagundam said. “Diabetes also can be effectively managed with physician-directed care.

“We want people to know they have the power to change their outcome.”

The program is directed by Registered Dietitian and Certified Diabetes Educator Beth Ackerman, who cited UofL’s own employee wellness program, Get Healthy Now, in earning the recognition.

“This recognition was made possible through collaboration with UofL Get Healthy Now and its director, Patricia Benson, assistant vice president for health, wellness and disease management,” Ackerman said. “We currently offer the program to UofL employees who are covered by the university’s health plan, and will begin offering it to other patients in January.”

The UofL Physicians Diabetes and Obesity Center works to:

• Elevate the health status of our community by raising awareness of the risks for diabetes and heart disease;
• Facilitate prevention and management programs;
• Be a resource to our patients and community health care providers; and 
• Support researchers in their efforts to fight the growing epidemic of diabetes and obesity.

The Diabetes and Obesity Center at UofL Physicians offers diabetes self-management education and support if a patient is newly diagnosed or has had diabetes for many years. The center’s diabetes educators assess each patient’s needs and help them individually or to enroll in an education class to meet those needs. Classes cover:

• Diabetes Prevention
• Diabetes Self-Management 
• Pregnancy Planning
• Diabetes Medications
• Diabetes and Technology
• Medical Nutrition Therapy
• Weight Management
• Monitored Activity Options

More than 84 million Americans – one in three adults – now have prediabetes. Of those 84 million, nine out of 10 of them don’t know they have it. Without intervention, many people with prediabetes could develop type 2 diabetes within five years.

In Kentucky, diabetes and prediabetes are at epidemic levels, according to the American Diabetes Association. More than 531,000 people in Kentucky, or 14.5 percent of the adult population, have diabetes. Of these, an estimated 108,000 have diabetes but don’t know it, greatly increasing their health risk. In addition, 1.168 million people in Kentucky – 35.5 percent of the adult population – have prediabetes with blood glucose levels higher than normal but not yet high enough to be diagnosed as diabetes. Every year an estimated 27,000 people in Kentucky are diagnosed with diabetes.

“More than 90 million adults in the United States are obese and more than 30 million adults suffer from diabetes. Our faculty, staff and students work every day to understand the causes and impacts of both so that we can develop the next generation of preventions, cures and treatments,” said UofL President Neeli Bendapudi, PhD. “This group of dynamic researchers now is looking at how our environment, in the broadest sense of the word, plays a role. This understanding has the potential to change not just people in Louisville, but literally the world. This is some of what makes UofL a great place to learn, work and invest.”

Aruni Bhatnagar, PhD, director of the UofL Diabetes and Obesity Center and the recently created Envirome Institute, which houses the Diabetes and Obesity Center, earned a competitive renewal grant that provides funding for essential core programs for all researchers in the center. Additionally, the center grant helps set the director of the research with an emphasis on metabolic and inflammatory mechanisms leading to diabetes, obesity and insulin resistance; stem cell biology; and environmental determinants of cardiometabolic disease. This marks the second successful five-year renewal that Bhatnagar has earned.

Petra Haberzettl, PhD, assistant professor of medicine, and Bradford Hill, PhD, associate professor of medicine, received funding to examine the effects of air pollution on stem cell health.

Jason Hellman, PhD, assistant professor of medicine, received funding to explore how exercise can reduce inflammation. His previous work has shown previously uncovered new mechanisms of sustained inflammation in atherosclerotic lesions in diet-induced obesity.

Matt Nystoriak, PhD, assistant professor of medicine, received support to study how the molecule carnosine can be activated in protecting humans against airborne particulate matter.

Timothy O’Toole, PhD, assistant professor of medicine, earned a competitive renewal grant to gain a better understanding of how diabetic conditions and pollutant exposure affects small pieces of genetic materials that line blood vessels.

The Diabetes and Obesity Center at the University of Louisville organized the congress to share new research on the health effects of histidyl dipeptides such as carnosine and anserine. It will be held at UofL’s Cardiovascular Innovation Institute, 302 E. Muhammad Ali Blvd., and the Brown Hotel, 335 W. Broadway.

Carnosine is known as an endogenous dipeptide that is naturally produced in the body. It is concentrated in skeletal muscles, the heart, the brain and other parts of the body. Carnosine is thought to prevent aging,  alleviate diet-induced metabolic syndrome, nerve damage, eye disorders and kidney problems.

Anserine is a derivative of carnosine and is normally absent from human tissues and body fluids.��Anserine is present in the skeletal muscle of birds and certain species of mammals, notably the rabbit, rat and whale. It is an antioxidant and helps reduce fatigue.��

The conference will draw leading scientists as presenters from four continents, with countries such as Australia, Azerbaijan, Belgium, Brazil, Canada, China, Germany, Italy, Japan, Poland, Russia, Slovakia and the United Kingdom represented as well as the United States.

The conference oral presentations will cover the impact of carnosine and anserine in exercise and sports,  chronic metabolic diseases, cardiovascular disease, cancer, the nervous system, renal disease and the biochemical pathways of carnosine and its derivatives.

Carnosine and anserine are referred to as novel dipeptides in science – meaning they consist of two amino acids and exhibit multifunctional properties. Recent clinical trials demonstrate that these dipeptides enhance the walking ability of patients with heart failure and alleviate metabolic syndrome in patients with diabetes.

“This congress provides an opportunity for researchers and scientists from around the world who are working in this area to interact and forge new collaborations,” said Assistant Professor of Medicine Shahid Baba, PhD, who is congress chair. “It allows investigators to interact with one another and forge collaborations that will help us advance research in this field.”

For details about the conference, contact Baba at 502-852-4274 or via email.

, was cited for conducting high-quality, high-impact research and exemplifying professionalism and integrity in research. The Research Exemplars were selected for their leadership and management skills in successfully running research laboratories and mentoring junior faculty.

“Aruni Bhatnagar’s commitment to research and to the development of the next generation of researchers is well known within the University of Louisville community,” said William Pierce, PhD, executive vice president for research and innovation.��“For his efforts to be distinguished by the Exemplar Project solidifies his place as one of the standard-bearers of research quality and integrity.”

UofL’s director of research integrity concurred. “Washington University in St. Louis and St. Louis University have a position of national leadership in the area of research professionalism. This award recognizes decades of Aruni’s work and affirms the critical role mentoring plays in the responsible and successful conduct of research,” said Allison Ratterman, PhD.

“I am honored to join my peers from across the United States as a Research Exemplar,” Bhatnagar said. “This program focuses on the intersection of leading a research lab and conducting high-quality, high-impact research with integrity and professionalism.

“To be included among this group is extremely gratifying and reaffirms my commitment to the role of research scientist.”

About Aruni Bhatnagar, PhD

Aruni Bhatnagar, PhD, holds dual professorships in medicine and in biochemistry and molecular biology. He joined UofL in 1998. Bhatnagar is a Distinguished University Scholar, director of the UofL Diabetes and Obesity Center and a Fellow of the American Heart Association.

Bhatnagar is also a leading environmental health scientist who led the creation of the field of environmental cardiology. Through multidisciplinary approaches, he has identified the influence of environmental factors that contribute to systemic inflammation and cardiovascular disease risk. His work has extended from basic bench research to national and global policy.

He has more than 200 peer-reviewed journal articles and $100 million in research support, he been a member of more than 50 review panels of the National Institutes of Health, Environmental Protection Agency and Department of Defense, and he currently serves as the deputy editor of the journal, Circulation Research.��

St. Margaret Mary School, 7813 Shelbyville Road, is the new site of an experiment designed to use trees and shrubs to create a living filter for roadway air pollution. The project will be a model for metro-wide “greening” projects that use our environment to improve health.

The Louisville Green for Good project is a collaboration among the Diabetes and Obesity Center at the , and the City of Louisville’s

The current levels of air pollution at the school will be measured and then half of the school’s front yard will be filled with a green buffer of shrubs, deciduous trees and pines. Then the team will measure air pollution levels a second time. The goal is to test the idea that a greener neighborhood is a healthier neighborhood.

“This project has the potential to improve the health of nearby students and residents for years to come by improving local air quality,” said Aruni Bhatnagar, PhD, the and director of the University of Louisville . “St. Margaret Mary was chosen due to its location which is close to a high traffic roadway. The school also includes a spacious lawn that allows for the addition of foliage, which will act as an air-cleansing barrier between the school and the street.”

said, “I am committed to helping Louisville become a greener and healthier place to live – and, I’m a data guy. So I’m excited that this project will provide the data we need to move forward on our sustainability goals for the city.”

Principal Wendy Sims said she is excited about this project for the parish, school and community.��

“In his ,’ Our Holy Father Pope Francis reminds us that ‘we must regain the conviction that we need one another, that we have a shared responsibility for others and for the world, and that being good and decent are worth it … social love moves us to devise larger strategies to halt environmental degradation and to encourage a “culture of care” which permeates all of society’,” Sims said. “This project is a wonderful lesson for our students, faculty, and parents about how to foster such a culture of care, now and for future generations.”

Air monitoring will start this summer. The trees and shrubs will arrive in October with a second round of air monitoring taking place later this year. Students will participate in the monitoring work.

In addition to tracking certain pollutants, the project team will collect data on traffic and weather.

The project includes ecology experts from around the country with deep understanding of air pollution and the power of plants.

Funding comes from the

The research effort is a project of the Funders’ Network for Smart Growth and Livable Communities. The grant was matched with $50,000 from the Owsley Brown Charitable Foundation and $25,000 from an anonymous donor in Louisville. The Institute for Healthy Air, Water, and Soil received the funds and will be managing the project.